Keep an eye on Intently (1)crofelemer increases levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Crofelemer has the prospective to inhibit CYP3A4 at concentrations envisioned while in the intestine; unlikely to inhibit systemically because minimally absorbed.Effect of coadministration of a twin CYP3A4